Erskine College is located in Due West, a town of 1,200 residents located in historic Abbeville County, South Carolina, an area rich in colonial, Revolutionary War, and Civil War history. The town and the college, with a number of antebellum buildings, are listed on the National Register of Historic Places. An annual spring festival brings a large number of tourists to share in the cultural and historic heritage of the county.
Due West is located near a number of lakes and recreational areas and within easy access to Interstate Routes 26 and 85 and the cities of Atlanta, Charlotte, Columbia, and Greenville. Greenwood and Anderson are each about 20 miles away. The town provides a restful and quiet atmosphere for study.